Histamine; Free Base

Code: 3779-1GM D2-231

General description

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

A potent vasodilator found in normal tissues and blood. For...


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General description

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-A in monocytes via H2 receptor activation.

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol.133, 178.Izumi, H., et al. 1995. Am. J. Obstet. Gynecol.172, 1477.Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem.269, 9952.Yan, Q.Z., et al. 1994. Agents Actions 41, C111.Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Packaging

Packaged under inert gas

1 g in Glass bottle

5 g in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)

assay≥97% (TLC)
colorwhite
formsolid
InChI keyNTYJJOPFIAHURM-UHFFFAOYSA-N
InChI1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilitywater: 1 mg/mL
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.2-8°C
Cas Number51-45-6
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