General description

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization; whereas, histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-A in monocytes via H₂ receptor activation.

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization, whereas histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol.133, 178.Izumi, H., et al. 1995. Am. J. Obstet. Gynecol.172, 1477.Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem.269, 9952.Yan, Q.Z., et al. 1994. Agents Actions 41, C111.Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Packaging

Packaged under inert gas

1 g in Glass bottle

5 g in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)